br tumor development by binding to promoter or enhancer
tumor development by binding to promoter or enhancer regions of related genes. Its impact on gastric cancer development has not been described. Based on the bioinformatics analysis results, we examined the status of NF-YA and cyclin E expression in paired samples of gastric cancer biopsies and non-cancerous counterparts acquired from 22 gastric cancer patients. Our results strongly suggest that NF-YA is an independent prog-nostic factor for gastric cancer patients. These results suggest that NF-YA might be involved in increasing the expression of cyclin E and in promoting gastric cancer development by increasing the expression of cell pro-liferation related genes.
The collective findings support the potential rela-tionship between cyclin E overexpression and the tran-scription factor NF-YA, both of which have strong prognostic value. NF-YA may promote the progression of gastric cancer by increasing the transcription of cyclin E and other Methoxy-X04 promoting genes. Targeting NF-YA may be a feasible therapeutic strategy in treating gastric cancer and further studies are warranted.
Conflicts of interest
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